2026

1. Hu R, Park J, Qian Y, Xiong S, Elsabbagh AH, Chhikara A, Fan H, Shi Z, Liu L, Li Y, Song Z, Mahmoud AM, Chen J, Baur JA, He Y, Layden BT, Zhou Z, Xu P, Ong SG, Wang Z, Jiang Y. ERalpha activates NAMPT/IL-33 signaling to enhance beige thermogenesis and metabolic fitness. Sci Adv. 2026;12(2):eadz1385. Epub 2026/01/07. doi: 10.1126/sciadv.adz1385. PubMed PMID: 41499496; PMCID: PMC12778055.
2. Xu G, Zhou J, Xu P, Gyawali I, Xu C, Yang J, Ma Z, Du D, Jiang Q, Shu G. Alpha‐Ketoglutarate Regulates Intestinal Motility and Health by OXGR1 in Nitrergic Neuron of Enteric Nervous System. Food Front. 2026;7(1). Epub 2026/01/09. doi: https://doi.org/10.1002/fft2.70216.

2025

1. Yu M, Feng B, Bean JC, Zhao Q, Yang Y, Liu H, Li Y, Eappen BP, Liu H, Tu L, Conde KM, Wang M, Chen X, Yin N, Threat DA, Xu N, Han J, Gao P, Zhu Y, Hadsell DL, He Y, Xu P, He Y, Wang C. Suppression of hypothalamic oestrogenic signal sustains hyperprolactinemia and metabolic adaptation in lactating mice. Nat Metab. 2025. Epub 2025/04/11. doi: 10.1038/s42255-025-01268-z. PubMed PMID: 40211044.
2. Zhang N, Yu M, Zhao Q, Feng B, Deng Y, Bean JC, Liu Q, Eappen BP, He Y, Conde KM, Liu H, Yang Y, Tu L, Wang M, Li Y, Yin N, Liu H, Han J, Threat DA, Xu N, Smiley T, Xu P, Chen L, Zeng T, He Y, Wang C. Altered thermal preference by preoptic estrogen receptor alpha neurons in postpartum females. Mol Metab. 2025;93:102108. Epub 2025/02/06. doi: 10.1016/j.molmet.2025.102108. PubMed PMID: 39909189.

2024

1. Yuan Y, Hu R, Park J, Xiong S, Wang Z, Qian Y, Shi Z, Wu R, Han Z, Ong SG, Lin S, Varady KA, Xu P, Berry DC, Shu G, Jiang Y. Macrophage-derived chemokine CCL22 establishes local LN-mediated adaptive thermogenesis and energy expenditure. Sci Adv. 2024;10(26):eadn5229. Epub 2024/06/26. doi: 10.1126/sciadv.adn5229. PubMed PMID: 38924414; PMCID: PMC11204298.
2. Ye H, Yang X, Feng B, Luo P, Torres Irizarry VC, Carrillo-Saenz L, Yu M, Yang Y, Eappen BP, Munoz MD, Patel N, Schaul S, Ibrahimi L, Lai P, Qi X, Zhou Y, Kota M, Dixit D, Mun M, Liew CW, Jiang Y, Wang C, He Y, Xu P. 27-Hydroxycholesterol acts on estrogen receptor alpha expressed by POMC neurons in the arcuate nucleus to modulate feeding behavior. Sci Adv. 2024;10(28):eadi4746. Epub 2024/07/12. doi: 10.1126/sciadv.adi4746. PubMed PMID: 38996023; PMCID: PMC11244552.
3. Torres Irizarry VC, Feng B, Yang X, Patel N, Schaul S, Ibrahimi L, Ye H, Luo P, Carrillo-Saenz L, Lai P, Kota M, Dixit D, Wang C, Lasek AW, He Y, Xu P. Estrogen signaling in the dorsal raphe regulates binge-like drinking in mice. Transl Psychiatry. 2024;14(1):122. Epub 2024/02/28. doi: 10.1038/s41398-024-02821-2. PubMed PMID: 38413577; PMCID: PMC10899193.
4. Park J, Hu R, Qian Y, Xiong S, El-Sabbagh AS, Ibrahim M, Wang J, Xu Z, Chen Z, Song Q, Song Z, Yan G, Mahmoud AM, He Y, Layden BT, Chen J, Ong SG, Xu P, Jiang Y. Estrogen counteracts age-related decline in beige adipogenesis through the NAMPT-regulated ER stress response. Nat Aging. 2024;4(6):839-53. Epub 2024/06/11. doi: 10.1038/s43587-024-00633-z. PubMed PMID: 38858606.

2023

1. Wu R, Park J, Qian Y, Shi Z, Hu R, Yuan Y, Xiong S, Wang Z, Yan G, Ong SG, Song Q, Song Z, Mahmoud AM, Xu P, He C, Arpke RW, Kyba M, Shu G, Jiang Q, Jiang Y. Genetically prolonged beige fat in male mice confers long-lasting metabolic health. Nat Commun. 2023;14(1):2731. Epub 2023/05/12. doi: 10.1038/s41467-023-38471-z. PubMed PMID: 37169793; PMCID: PMC10175245.
2. Munoz MD, Zamudio A, McCann M, Gil V, Xu P, Liew CW. Activation of brown adipose tissue by a low-protein diet ameliorates hyperglycemia in a diabetic lipodystrophy mouse model. Sci Rep. 2023;13(1):11808. Epub 2023/07/22. doi: 10.1038/s41598-023-37482-6. PubMed PMID: 37479751; PMCID: PMC10362023.
3. Feng B, Liu H, Mishra I, Duerrschmid C, Gao P, Xu P, Wang C, He Y. Asprosin promotes feeding through SK channel-dependent activation of AgRP neurons. Sci Adv. 2023;9(8):eabq6718. Epub 2023/02/23. doi: 10.1126/sciadv.abq6718. PubMed PMID: 36812308; PMCID: PMC9946352.

2022

1. Yuan Y, Zhu C, Wang Y, Sun J, Feng J, Ma Z, Li P, Peng W, Yin C, Xu G, Xu P, Jiang Y, Jiang Q, Shu G. alpha-Ketoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling. Sci Adv. 2022;8(18):eabn2879. Epub 2022/05/05. doi: 10.1126/sciadv.abn2879. PubMed PMID: 35507647; PMCID: PMC9067931.
2. Yu M, Bean JC, Liu H, He Y, Yang Y, Cai X, Yu K, Pei Z, Liu H, Tu L, Conde KM, Wang M, Li Y, Yin N, Zhang N, Han J, Scarcelli NA, Xu P, He Y, Xu Y, Wang C. SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis. Cell Biosci. 2022;12(1):170. Epub 2022/10/10. doi: 10.1186/s13578-022-00907-2. PubMed PMID: 36210455; PMCID: PMC9549684.
3. Ye H, Feng B, Wang C, Saito K, Yang Y, Ibrahimi L, Schaul S, Patel N, Saenz L, Luo P, Lai P, Torres V, Kota M, Dixit D, Cai X, Qu N, Hyseni I, Yu K, Jiang Y, Tong Q, Sun Z, Arenkiel BR, He Y, Xu P, Xu Y. An estrogen-sensitive hypothalamus-midbrain neural circuit controls thermogenesis and physical activity. Sci Adv. 2022;8(3):eabk0185. Epub 2022/01/20. doi: 10.1126/sciadv.abk0185. PubMed PMID: 35044814.
4. Torres Irizarry VC, Jiang Y, He Y, Xu P. Hypothalamic Estrogen Signaling and Adipose Tissue Metabolism in Energy Homeostasis. Front Endocrinol (Lausanne). 2022;13:898139. Epub 2022/06/28. doi: 10.3389/fendo.2022.898139. PubMed PMID: 35757435; PMCID: PMC9218066.